| 摘要 |
Disclosed herein is a use of an anti-dysrhythmic treating agent and a pharmaceutically acceptable bioadhesive carrier that releases the treating agent over an extended period of time after administration, in the manufacture of a medicament for vaginal administration in the treatment or prevention of pelvic pain, or in improving infertility, wherein the pain or infertility is associated with uterine dysrhythmia. The pharmaceutically acceptable bioadhesive carrier comprises a bioadhesive, water-swellable, water-insoluble, cross-linked polycarboxylic acid polymer, such as polycarbophil. The anti-dysrhythmic treating agent may comprise one or more agents selected from the group consisting of coronary and-arrhythmic, local anesthetics (such as lidocaine), calcium channel blocker, autocoid agents, prostaglandin blockers, non-steroidal anti-inflammatory drugs, COX inhibitors, thromboxane synthase inhibitors, and leukotriene inhibitors.
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