GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP

摘要

Disclosed is a glucocorticoid receptor agonist composed of a compound represented by formula (1) or a salt thereof, which is a 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative having a substituted oxy group.  A novel pharmacological action of the agonist is also disclosed.  In the formula, R1 represents a group represented by formula (2a), (3a), (4a) or (5a); R2 represents -(CO)-R8, -(CO)O-R9 or the like; R2-O- is substituted at the 4-position or the 5-position of the benzene ring A; R3 represents a lower alkyl group; R4, R5, R6 or R7 represents a halogen atom, an optionally substituted lower alkyl group or the like; m, n, p or q represents 0, 1 or the like; and R8, R9 or the like represents an optionally substituted lower alkyl group, a lower alkenyl group or the like.