Substituted heterocyclic compounds for disease treatment

摘要

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted heterocyclic amine derivative compound and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

主权项

1. A compound of Formula (A) or tautomer, stereoisomer, geometric isomer or a pharmaceutically acceptable salt, or N-oxide thereof:wherein,
Ring A is a 1,3-disubstituted pyridine selected from the group consisting of: each R14 is independently selected from hydrogen, halogen, OR9, alkyl, or fluoroalkyl; G is —X—Y; X is selected from —C(R9)2—C(R9)2—, —C(R9)═C(R9)—, —C≡C—, and —C(R9)2—O—; Y is selected from:
C3-C15 alkyl optionally substituted with a substituent chosen from halo, hydroxy, alkoxy, or fluoroalkyl;C3-C10 carbocyclyl optionally substituted with a substituent chosen from halo, hydroxy, alkyl, alkoxy, or fluoroalkyl;carbocyclyalkyl optionally substituted with a substituent chosen from halo, hydroxy, alkyl, alkoxy, or fluoroalkyl;aryl optionally substituted with a substituent chosen from halo, hydroxy, alkyl, alkoxy, or fluoroalkyl; oraralkyl optionally substituted with a substituent chosen from halo, hydroxy, alkyl, alkoxy, or fluoroalkyl; R1 and R2 are each independently selected from hydrogen, or —OR9; or R1 and R2 form an oxo; or optionally, R1 and R3 together form a direct bond to provide a double bond; or optionally, R1 and R3 together form a direct bond, and R2 and R4 together form a direct bond to provide a triple bond; R3 and R4 are hydrogen; R5 and R6 are hydrogen; R7 and R8 are each independently selected from hydrogen, C1-C3 alkyl, or —C(═O)R13; R9 is hydrogen; R13 is C1-C3 alkyl.