发明名称 |
MUCOSAL MEMBRANE RECEPTOR AND USES THEREOF |
摘要 |
The invention is based on the identification of aminopeptidase N (APN) as the receptor for F4 fimbriae of enterotoxigenic E. coli (ETEC). Based on the observation that oral administration of F4 fimbriae induces a protective intestinal mucosal immune response against a subsequent challenge with F4 ETEC, and the observation that the internalization of said F4 fimbriae is clathrin-mediated, the present invention provides the characterization of APN as a target useful in: in an in vitro assay to screen for molecules that are capable to mimic the clathrin-mediated F4 endocytosis; in an in vitro assay to screen for molecules that are capable to modulate the binding of F4 fimbriae with APN; in the development of a carrier for the delivery of antigens / therapeutics, i.e. immunomodulators to the intestinal submucosa or the intestinal mucosa-associated lymphoid tissue, wherein said carrier comprises an APN specific target molecule that mimics the clathrin-mediated F4 endocytosis. The use of the carriers thus identified or the treatments thus identified, in a method of inducing an antigen specific intestinal mucosal immune response, and/or in the treatment of bacterial diarrhea, is a further aspect of the present invention. |
申请公布号 |
WO2009103555(A3) |
申请公布日期 |
2009.11.05 |
申请号 |
WO2009EP01238 |
申请日期 |
2009.02.20 |
申请人 |
UNIVERSITEIT GENT;RASSCHAERT, KRISTIEN;GODDEERIS, BRUNO;COX, ERIC;DEFORCE, DIETER |
发明人 |
RASSCHAERT, KRISTIEN;GODDEERIS, BRUNO;COX, ERIC;DEFORCE, DIETER |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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