PIPERAZINE-BASED CCR5 ANTAGONIST TABLET DOSAGE FORM

摘要

Tablets containing 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[4-[2-methoxy-1(R)-[4-(trifluoromethyl)phenyl]ethyl]-3-(S)-methyl-1-piperazinyl]-4-methyl-piperi dine or a pharmaceutically acceptable salt thereof are disclosed. Methods of making such tablets with satisfactory processability are also disclosed. In addition, methods for treating HIV as well as inflammatory diseases with an antagonist of chemokine (C-C motif) receptor 5 (CCR5) are disclosed.