| 摘要 |
For the separation, removal, isolation, purification, characterisation, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-Cl or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR2; Z is O, S or N-R3; R2 and R3 are each H, C1-6 alkyl, Cu, hydroxyalkyl, benzyl or phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH2)3-4-NH2; and R7 is a group bearing a positive charge at neutral pH. |
