POROUS HOLLOW SILICA N ANOP ARTICLES, PREPARATION METHOD OF THE SILICA NANOPARTICLES, AND DRUG CARRIERS AND PHARMACEUTICAL COMPOSITION COMPRISING THE SILICA NANOPARTICLES

摘要

Porous hollow silica nanoparticles are provided. Each of the silica nanoparticles comprises a core having a large inner cavity and a porous silica shell surrounding the core. Due to the presence of the cavities in the cores, the porous hollow silica nanoparticles exhibit much higher drug loading efficiency than conventional particles for drug carriers. In addition, the pore size range of the porous silica shells is optimized by surface functional groups bonded to the silica shells and/or a biocompatible polymer bonded to the silica shells via the surface functional groups to ensure a steady and stable release of a drug from the silica nanoparticles. Therefore, the porous hollow silica nanoparticles can be effectively used for the preparation of drug carriers. Further provided are a method for the preparation of the silica nanoparticles and drug carriers comprising the silica nanoparticles.