Compounds of formula Ic:
or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to the use of the compounds of the present invention for the preparation of a medicament for treating ABC transporter mediated diseases, like cystic fibrosis.
申请公布号
ZA200809290(B)
申请公布日期
2009.10.28
申请号
ZA20080009290
申请日期
2008.10.29
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
RUAH, SARA S. HADIDA;GROOTENHUIS, PETER D. J.;VAN GOOR, FREDRICK;ZHOU, JINGLAN;BEAR, BRIAN;MILLER, MARK T.;MCCARTNEY, JASON;NUMA, MEHDI MICHEL JAMEL