发明名称 |
Simian immunodeficiency virus (SIV) molecular clone encoding mutant gag gene lacking inhibitory/instability regions |
摘要 |
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.
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申请公布号 |
US7608422(B2) |
申请公布日期 |
2009.10.27 |
申请号 |
US20030644027 |
申请日期 |
2003.08.19 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PAVLAKIS GEORGE N. |
分类号 |
C12N15/09;C12P21/06;A61K31/7052;A61K39/00;A61K39/21;A61K48/00;A61P31/18;A61P37/04;C07H21/04;C07K14/155;C07K14/16;C12N1/21;C12N5/00;C12N5/08;C12N5/10;C12N7/00;C12N15/00;C12N15/867 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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