On-Chip Cell Migration Detection

摘要

Techniques, systems and apparatus are disclosed for detecting impedance. In one aspect, to monitor cell migration, a chemical coating layer is applied on at least a portion of a surface of each sensing electrode in a microelectrode sensing device that includes a counter electrode and a plurality of sensing electrodes to inhibit adhesion of target cells on the surface of each sensing electrode. The target cells are seeded in the microelectrode sensing device to allow the seeded target cells to adhere to areas outside of the surface of each sensing electrode. An electrical signal is applied to each sensing electrode to desorb the applied chemical coating layer from the surface of each sensing electrode. A change in electrical impedance measured by each sensing electrode is detected in response to one or more of the seeded target cells migrating onto the surface of each sensing electrode.