| 摘要 |
<p>A film-coated tablet/granules comprising core containing pyridylpyrimidine compound (c1), or its salt (25 - 80 wt.%) (preferably imatinib or its monomethanesulfonate salt) and at least one filler-binder, and optionally other additives, is produced by pressing the starting materials, in which prior to pressing at least one of them has been dry-granulated (preferably compressed or compacted). Independent claims are included for the following: (1) production of the film-coated tablet or granules involving producing the tablet cores and the granules by pressing of the starting materials and, prior to pressing of the starting materials, at least one of them is dry-granulated (preferably compressed or compacted); and coating the resulting tablet cores and optionally granules with a film, where the starting materials contain the compound (c1) and at least one compound acting as filler-binder, and optionally other additives in the mixture, and the compound (c1) is present in an amount of 25 - 80 wt.%; (2) the tablet cores and granule cores which are not provided with a film coating and which are used as intermediates for the production of film-coated tablets and film-coated granules; and (3) powder mixtures which are used as intermediates for the production of the tablet cores and granule cores. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : Tyrosine kinase inhibitor. No biological data given.</p> |
