发明名称 AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
摘要 The invention provides amino- and amido-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, and n are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
申请公布号 US2009247627(A1) 申请公布日期 2009.10.01
申请号 US20090414900 申请日期 2009.03.31
申请人 TRAPP SEAN G;LEADBETTER MICHAEL R;LONG DANIEL D;JIANG LAN;AXT SABINE 发明人 TRAPP SEAN G.;LEADBETTER MICHAEL R.;LONG DANIEL D.;JIANG LAN;AXT SABINE
分类号 C07C237/26;A61K31/165;A61K31/17;A61K31/18;A61K31/27;A61P1/00;C07C261/02;C07C275/24;C07C311/13;C07C335/12;C12Q1/02 主分类号 C07C237/26
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