发明名称 |
Nucleic acids useful for triggering tumor cell lethality |
摘要 |
The invention relates to double-stranded nucleic acid fragments comprising a chemically modified backbone and at least 4-1000 bp, preferably 8-500 bp, and most preferably 16-200 bp. The disclosed molecules (DRIL molecules) may interfere with DNA damage signaling and repair pathways, in particular the non homologous NHEJ pathway of double-stranded break repair. The invention discloses the application of the DRIL molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumoral cell nuclei in order to trigger DNA repair induced lethality (DRIL in short) of tumoral cells/tissues.
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申请公布号 |
US7595302(B2) |
申请公布日期 |
2009.09.29 |
申请号 |
US20040576818 |
申请日期 |
2004.10.25 |
申请人 |
INSTITUT CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);MUSEUM NATIONAL D'HISTOIRE NATURELLE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
DUTREIX MARIE;SUN JIAN-SHENG |
分类号 |
A61K31/70;A61K31/7088;A61K31/7105;A61K31/711;A61K31/7115;A61K31/712;A61K31/7125;A61K31/713;A61K38/00;C07H21/00;C07H21/04;C12N15/11;C12P19/34;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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地址 |
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