发明名称 |
Thermophillic Organisms For Conversion Of Lignocellulosic Biomass To Ethanol |
摘要 |
Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture involving a substrate concentration challenge lead to evolution of ALK1, and formation of a more robust strain designated ALK2. Both organisms produce near theoretical ethanol yields without expressing pyruvate decarboxylase
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申请公布号 |
US2009239277(A1) |
申请公布日期 |
2009.09.24 |
申请号 |
US20090398876 |
申请日期 |
2009.03.05 |
申请人 |
THE TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
SHAW, IV ARTHUR JOSEPHUS;DESAI SUNIL G.;LYND LEE R.;TYURIN MIKHAIL V. |
分类号 |
C12P7/06;C12N1/21;C12N15/00;C12N15/11 |
主分类号 |
C12P7/06 |
代理机构 |
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地址 |
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