PROCESS FOR PREPARING COMPOUNDS CONTAINING A HYDRONAPHTALENE STRUCTURE WITH AN UNSYMMETRICALLY SUBSTITUTED BENZENE RING

摘要

Process for preparing a compound according to formula (I) or (Ia) in a high enantiomeric excess, Formulae (I), (Ia), the process comprising reacting a nucleophile of formula R1NHR2 with a chiral compound of formula (II), in the form of a racemate, Formula (II), in the presence of a rhodium-based catalytic system which comprises a chiral diphosphine ligand, as well as compounds made by that process and the use of that process or those compounds for preparing active pharmaceutical ingredients (APIs).