Cyclopropyl derivatives as NK3 receptor antagonists

摘要

Disclosed is a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, or 2, Q is selected from (i), (ii), or (iii), and wherein the other substituents are as defined in the specification. Also disclosed is the use of the compound to treat psychotic disorders, schizophrenia, depression, anxiety, Parkinson's disease, pain, convulsions, cough, asthma, airway hyperresponsiveness, microvascular hypersensitivity, bronchoconstriction, gut inflammation, inflammatory bowel disease, hypertension, imbalances in water and electrolyte homeostasis, ischemia, oedema, plasma extravasation, obesity, and schizophrenia.