QUINOXALINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF HAVING MCH1R INHIBITORY ACTIVITY, PROCESS FOR PREPARATION AND USE THEREOF FOR TREATING OBESITY

摘要

A quinoxaline derivatives having activity of suppressing melanin-concentrating hormone 1 receptor (MCH1R) is provided to treat diseases related to obesity caused by the activation of MCH1R. A quinoxaline derivative of the chemical formula 1 has the activation of suppressing a melanin-concentrating hormone receptor (MCH1R). A method for manufacturing the quinoxaline derivative of the chemical formula 1 comprises: a first step of condensing a compound of the chemical formula 3 with 2-chloro-6-nitroquinoxaline compound of the chemical formula 2 to produce a 6-nitroquinoxaline derivative of the chemical formula 4; a second step of reducing the 6-nitroquinoxaline derivative of the chemical formula 4 to produce a 6-aminoquinoxaline derivative of the chemical formula 5; and a third step of condensing biphenyl-4-carboxylic acid compound of the chemical formula 6 with the aminoquinoxaline derivative of the chemical formula 5 to a quinoxaline derivative which 6-(biphenyl-4-carboxamido) group is substituted.