Use of thiazole inhibitors of fatty acid oxidation of formula (I) for the treatment of Alzheimer's disease and other neurological conditions

摘要

Methods for inhibiting and/or reversing tau filament formation or polymerization are provided. These methods can be used for treating certain neurological disorders in vivo by administering pharmaceutical compositions which inhibit and/or reverse tau filament formation or polymerization. An especially preferred pharmaceutical composition contains an inhibitor of the general formula (I), wherein R 1 is an aliphatic radical having one to six carbon atoms and wherein R 2 and R 3 independently are a second aliphatic radical having one to six carbon atoms, a hydroxyl-substituted aliphatic radical having one to six carbon atoms, or a pheny radical or a pharmaceutically acceptable salt of the inhibitor.