发明名称 Propane-1,3-Dione Derivative or Salt Thereof
摘要 It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by -SO2-R3 in a propane-1,3-dione derivative having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene) has an excellent GnRH receptor antagonistic effect and accomplished the present invention. Because the compound of the present invention has a potent GnRH receptor antagonistic effect, it is useful for the treatment of sex hormone-dependent diseases, particularly GnRH-related diseases. Further, because the compound of the present invention has an excellent metabolic stability in human and few drug interactions, therefore it has preferable characteristics as a pharmaceutical used for the above-mentioned diseases.
申请公布号 US2009181964(A1) 申请公布日期 2009.07.16
申请号 US20060887384 申请日期 2006.03.30
申请人 ASTELLAS PHARMA INC. 发明人 HIRANO MASAAKI;KINOYAMA ISAO;MATSUMOTO SHUNICHIRO;KAWAMINAMI EIJI;OHNUKI KEI;YAMAMOTO HIROFUMI;OSODA KAZUHIKO;TAKAHISA TATSUHISA;SHIN TAKASHI;KOIKE TAKANORI;SHIMADA ITSURO;HISAMICHI HIROYUKI;KUSAYAMA TOSHIYUKI
分类号 A61K31/5377;A61K31/4184;A61K31/4439;A61K31/496;A61K31/501;A61K31/506;A61P35/00;C07D235/04;C07D401/02;C07D403/02;C07D413/14 主分类号 A61K31/5377
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