发明名称 BISPECIFIC ANTI-ERB-B ANTIBODIES AND THEIR USE IN TUMOR THERAPY
摘要 The invention relates to pharmaceutical compositions comprising different molecules, preferably monoclonal antibodies, each comprising epitopes that bind simultaneously to different sites within the same ErbB receptor domain, preferably the ErbB1 receptor domain. The preferred antibodies according to this invention are MAb 425 and MAb 225 each in its murine, chimeric and humanized version. The invention relates to the use and methods for an improved treatment of preferably tumors by means of said compositions.
申请公布号 HK1081448(A1) 申请公布日期 2009.07.03
申请号 HK20060101772 申请日期 2006.02.10
申请人 MERCK PATENT GMBH 发明人 KREYSCH, HANS-GEORG
分类号 A61K;A61K39/395;C07K;C07K16/28;C07K16/32 主分类号 A61K
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