A method for inhibition of leukemic stem cells expressing IL-3Ra; (CD 123), comprises contacting the cells with an antigen binding molecule comprising a Fc region or a modified Fc region having enhanced Fc effector function, wherein the antigen binding molecule binds selectively to IL-3Ra (CD123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule.
申请公布号
WO2009070844(A1)
申请公布日期
2009.06.11
申请号
WO2008AU01797
申请日期
2008.12.04
申请人
CSL LIMITED;UNIVERSITY HEALTH NETWORK;DICK, JOHN EDGAR;JIN, LIQING;VAIRO, GINO LUIGI;GEARING, DAVID, PAUL;BUSFIELD, SAMANTHA, JANE
发明人
DICK, JOHN EDGAR;JIN, LIQING;VAIRO, GINO LUIGI;GEARING, DAVID, PAUL;BUSFIELD, SAMANTHA, JANE