METHOD OF TREATING OR PREVENTING PATHOLOGIC EFFECTS OF ACUTE INCREASES IN HYPERGLYCEMIA AND/OR ACUTE INCREASES OF FREE FATTY ACID FLUX

摘要

One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.