GENE TARGETS FOR ENHANCED CAROTENOID PRODUCTION

摘要

The present invention provides engineered cells and methods for utilizing same. Methods for producing carotenoids or for enhanced carotenoid synthesis utilizing cells with enhanced dxs, idi, or ispFD gene expression, diminished or abrogated gdhA, aceE, fdhF, yjiD, hnr or yjfP gene expression or any combination thereof and diminished or abrogated ackA, appY, aspC, clp, clpP, clpXP, crcB, csdA, cyaA, evgS, fdhA, fdhD, feoB, fumA, glnE, glxR, gntK, hycI, lipB, lysU, modA, moeA, nadA, nuoC, nuoK, pflB, pitA, pst, pstC, pta, yjiD, sohA, stpA, yagR, yaiD, ybaS, ycfZ, ydeN, yebB, yedN, yfcC, ygjP, yibD, yjfP, yjhH, or yliE gene expression, or a combination thereof are disclosed. Genes with diminished or abrogated expression may have inhibited expression, activity or function.