发明名称 |
Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein |
摘要 |
Disclosed are compositions comprising non-steroid anti-inflammatory drugs (NSAID's) complexed with zwitterionic, neutral phospholipids, or both, having reduced gastrointestinal irritating effects and enhanced anti-pyretic, analgesic, and anti-inflammatory activity. Also disclosed are improved methods of using the complexes for treating fever, inflammation, and preventing platelet aggregation. In some embodiments, the anti-pyretic activity of sub-therapeutically used amounts of NSAID's are enhanced to elicit anti-pyretic activity in vivo when associated (noncovalently) with zwitterionic phospholipids, such as dipalmitoyl phosphatidyl choline. |
申请公布号 |
EP2065047(A1) |
申请公布日期 |
2009.06.03 |
申请号 |
EP20090003432 |
申请日期 |
1996.01.24 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
LICHTENBERGER, LENARD, M.;BUTLER, BRUCE, D. |
分类号 |
A61K31/74;A61K31/19;A61K31/192;A61K31/195;A61K31/196;A61K31/405;A61K31/60;A61K31/66;A61K47/44;A61P29/00 |
主分类号 |
A61K31/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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