| 发明名称 |
QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY |
| 摘要 |
<p>The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below. These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.</p> |
| 申请公布号 |
EP2061773(A2) |
申请公布日期 |
2009.05.27 |
| 申请号 |
EP20070842116 |
申请日期 |
2007.09.10 |
| 申请人 |
CURIS, INC. |
发明人 |
QIAN, CHANGGENG;CAI, XIONG;GOULD, STEPHEN;ZHAI, HAIXIAO |
| 分类号 |
A61K31/517;A61P35/00;C07D239/94;C07D401/12;C07D403/12;C07D405/04;C07D405/12;C07D409/12 |
主分类号 |
A61K31/517 |
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