The invention relates to the synthesis of polyketides in Actinomycetes by overexpression of pantothenate kinase and supplementation with pantothenic acid. This results in increasing in vivo CoA production and thereby drives increased production of secondary metabolites, such as polyketides.
申请公布号
WO2008039177(A3)
申请公布日期
2009.05.22
申请号
WO2006US37107
申请日期
2006.09.22
申请人
RICE UNIVERSITY;LEE, HEI CHAN;SOHNG, JAE KYUNG;SAN, KA-YIU