发明名称 ORAL STANNOUS COMPOSITIONS
摘要 The present invention relates to an aqueous oral composition comprising: a) from 0.2% to 3% divalent metal ions comprising: i. from 0.1% to 1.5% of zinc ions; ii. from 0.1% to 2% of tin (II) ions; and b) a source of fluoride ions; c) a silica dental abrasive; d) one or more chelants having a MW of less than 1000 and capable of forming water-soluble complexes with the zinc ions, wherein the chelants comprise less than 0.2% linear polyphosphates having a chain length of four or more; e) an orally acceptable carrier comprising at least 20% total water; wherein the pH of the composition is from 5 to 6.5, the molar ratio of the chelants to the divalent metal ions is at least 0.70: 1 and at least 80% by weight of the total zinc ions are solubilised within the composition. The composition of the invention has been found to give improved antimicrobial activity from the zinc / stannous combination without significant taste, staining or stability problems, compared to compositions having lower levels of chelants.
申请公布号 CA2703078(A1) 申请公布日期 2009.05.14
申请号 CA20082703078 申请日期 2008.11.04
申请人 THE PROCTER & GAMBLE COMPANY 发明人 STRAND, ROSS;PRENDERGAST, MAURICE JOSEPH;WANG, XIAOLI
分类号 A61K8/19;A61K8/21;A61K8/25;A61K8/27;A61K8/55;A61Q11/00 主分类号 A61K8/19
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