发明名称 |
METHODS, USES AND COMPOSITIONS FOR MODULATING REPLICATION OF HCV THROUGH THE FARNESOID X RECEPTOR (FXR) ACTIVATION OR INHIBITION |
摘要 |
The present invention relates to uses, methods and compositions for modulating replication of viruses of the Flaviviridae family, such as hepatitis C virus, through the farnesoid X receptor (FXR) activation or inhibition. More specifically, the invention relates to the use of an antagonist of FXR or an inhibitor of expression thereof for the manufacture of a medicament intended for treating a Flaviviridae virus infection in a subject in need thereof. The invention encompasses the use of antagonists of FXR, such as guggulsterone, or use of inhibitors of FXR expression. The invention relates also to a cell culture system allowing the replication of HCV and to methods for diagnosing HCV infection, screening of anti-viral compounds and vaccine or viral protein production. |
申请公布号 |
WO2008017692(A3) |
申请公布日期 |
2009.04.30 |
申请号 |
WO2007EP58239 |
申请日期 |
2007.08.08 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);ANDRE, PATRICE;LOTTEAU, VINCENT;SCHOLTES, CAROLINE |
发明人 |
ANDRE, PATRICE;LOTTEAU, VINCENT;SCHOLTES, CAROLINE |
分类号 |
A61K31/57;A61P31/14;C12N15/113 |
主分类号 |
A61K31/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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