Vaccine for prevention and treatment of HIV-infection

摘要

This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which is a fusion of HIV antigens comprising at least four HIV antigens or immunogenic fragments or derivatives, wherein the four antigens or fragments are or are derived from Nef, Pol and Gag.