SCREENING METHOD FOR THE COMPOSITION FOR PREVENTION OR TREATMENT OF OSTEOPOROSIS AND METABOLIC BONE DISEASE USING TALLYHO/JNGJ MOUSE

摘要

Provided is a method for screening a composition for preventing or treating an osteoporosis and a metabolic bone disease using a TALLYHO/ JngJ mouse, and more particularly, to a method for screening a compound effective in preventing and treating a disease caused by abnormalities of a bone metabolism including an osteoporosis, through assessment of a bone regeneration activity, such as acceleration of osteoblast differentiation, inhibition of osteoclast differentiation, variation of cytokine in a serum, as well as a bone mineral density and a bone mineral content in a femur, using a TALLYHO/ JngJ mouse instead of a ovariectomized animal generally used in estimating the efficacy of a new osteoporosis medicine in an animal. The screening method has a simple and stable experiment procedure, and can be used in developing an agent for treating an osteoporosis of men and improving the bone mineral content. Therefore, the method can be used in estimating an indirect efficacy on the metabolic bone disease and the osteoporosis.