The present invention provides crystals of a topoisomerase polypeptide and a nucleic acid. The crystals are of use in elucidating the structure of topoisomerase-nucleic acid complexes. Moreover, the crystals are of use in the discovery of ligands that interact with topoisomerase- nucleic acid complexes and modulate the activity of such complexes through this interaction.
申请公布号
WO2008154432(A3)
申请公布日期
2009.03.26
申请号
WO2008US66194
申请日期
2008.06.06
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;BERGER, JAMES, M.;DONG, KEN;SCHEOFFLER, ALLYN, J.
