Process for preparation of substituted amino alcohols

摘要

There is provided a process for the preparation of substituted amino alcohols HO-(CH2)n-NR1R2 from haloalcohols HO-(CH2)n-X, where X is Cl, Br or I, by reaction with an amine HNR1R2, in water as solvent at a temperature range of about 20° C. to about 90° C. optionally in the presence of a catalytic amount of an iodide source metal iodides. The haloalcohols are useful in the preparation of 6-[(substituted)phenyl]-triazolopyrimidine compounds which are useful in the treatment of cancer.