发明名称 |
CELL PERMEABLE NM23 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTI-METASTATIC COMPOSITION COMPRISING THE SAME |
摘要 |
The present invention discloses cell permeable Nm23 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a metastasis suppressor Nm23. Also disclosed are polynucleotides encoding the cell permeable Nm23 recombinant proteins, an expression vector containing the cell permeable Nm23 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable Nm23 recombinant protein as an effective ingredient. The cell permeable Nm23 recombinant proteins of the present invention can induce KSR phosphorylation and inactivation and inhibit Ras-mediated MAPK cascade by efficiently introducing a metastasis suppressor Nm23 into a cell. Therefore, the cell permeable Nm23 recombinant proteins of the present invention can be effectively used as an anti- metastatic agent capable of preventing cancer metastasis by inhibiting the proliferation, differentiation and migration of cancer cells. |
申请公布号 |
WO2009031835(A2) |
申请公布日期 |
2009.03.12 |
申请号 |
WO2008KR05221 |
申请日期 |
2008.09.04 |
申请人 |
INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY;JO, DAEWOONG;DO, THI THUY NGA;PARK, KISUK |
发明人 |
JO, DAEWOONG;DO, THI THUY NGA;PARK, KISUK |
分类号 |
C12N15/12;A61K38/17;C07H21/02 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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