| 发明名称 |
RAF inhibitors and their uses |
| 摘要 |
The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
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| 申请公布号 |
US7501430(B2) |
申请公布日期 |
2009.03.10 |
| 申请号 |
US20070785163 |
申请日期 |
2007.04.16 |
| 申请人 |
ARQULE, INC. |
发明人 |
LAPIERRE JEAN-MARC;NAMDEV NIVEDITA D.;ASHWELL MARK A.;FRANCE DENNIS S.;WU HUI;HUTCHINS PATRICK M.;TANDON MANISH;LIU YANBIN;LINK JEFF S.;ALI SYED M.;BRASSARD CHRIS J.;NICEWONGER ROBB B.;FILIKOV ANTON;CARAZZA REBECCA J. |
| 分类号 |
C07D498/04;A61K31/4188;A61K31/429;C07D513/04 |
主分类号 |
C07D498/04 |
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