发明名称 Cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs
摘要 Compounds of Formula I, their preparation and synthetic intermediates, and their use in the synthesis of prodrugs: wherein: V and L are trans relative to one another; V is selected from group consisting of carbocyclic aryl, substituted carbocyclic aryl, heteroaryl, and substituted heteroaryl; and L is a leaving group selected from the group consisting of halogen, alkyl sulfonate, aryloxy optionally substituted with 1-2 substituents, N-containing heteroaryl, and N-hydroxy-nitrogen containing heteroaryl; and salts thereof.
申请公布号 US7498320(B2) 申请公布日期 2009.03.03
申请号 US20060528283 申请日期 2006.09.28
申请人 METABASIS THERAPEUTICS, INC. 发明人 REDDY K. RAJA;CRAIGO WILLIAM;SUN ZHILI;BOYER SERGE;UGARKAR BHEEMARAO G.
分类号 A61K31/665;A61P31/12;A61P35/00;C07F9/02;C07F9/6574;C07H19/04 主分类号 A61K31/665
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