The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
申请公布号
ZA200803153(B)
申请公布日期
2009.02.25
申请号
ZA20080003153
申请日期
2008.04.10
申请人
MEDAREX INC.
发明人
BOYD, SHARON ELAINE;CHEN, LIANG;GANWAR, SANJEEV;GUERLAVAIS, VINCENT;HORGAN, KILLIAN;SUFI, BILAL;HUANG, HAICHUN;KING, DAVID JOHN;PAN, CHIN;CARDARELLI, JOSEPHINE M.