| 发明名称 |
Recombinant terminal deoxynucleotidyl transferase with improved functionality |
| 摘要 |
Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus, characterized in that the derivative in comparison to the native TdT is N-terminally truncated by up to 161 amino acids and has a 20- to 30-fold higher enzyme activity in solutions containing Co2+ ions, and its recombinant production and use.
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| 申请公布号 |
US7494797(B2) |
申请公布日期 |
2009.02.24 |
| 申请号 |
US20030406136 |
申请日期 |
2003.04.03 |
| 申请人 |
ROCHE DIAGNOSTICS OPERATIONS, INC. |
发明人 |
MUELLER RAINER;PAJATSCH MARKUS;CURDT INGO;SOBEK HARALD;SCHMIDT MANFRED;SUPPMANN BERNHARD;SONN KIRSTEN;SCHNEIDINGER BERND |
| 分类号 |
C12N9/12;C12N15/09;C07K1/00;C12N9/00;C12N15/54;C12Q1/48 |
主分类号 |
C12N9/12 |
| 代理机构 |
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