| 发明名称 |
STABILIZATION OF ENVELOPE GLYCOPROTEIN TRIMERS BY DISULFIDE BONDS INTRODUCED INTO A GP41 GLYCOPROTEIN ECTODOMAIN |
| 摘要 |
The present application is directed to stabilized envelope glycoprotein trimers. The trimers are stabilized by introducing disulfide bonds at certain sites in the gp41 ectodomain. DNA molecules encoding such trimers can be used to generate an immunogenic reaction.
|
| 申请公布号 |
CA2305341(C) |
申请公布日期 |
2009.01.06 |
| 申请号 |
CA19982305341 |
申请日期 |
1998.10.01 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
SODROSKI, JOSEPH G.;FARZAN, MICHAEL |
| 分类号 |
C12N15/49;A61K38/00;A61K39/21;A61P31/18;C07K14/16;C12N15/48 |
主分类号 |
C12N15/49 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
