| 发明名称 |
Motif-grafted hybrid polypeptides and uses thereof |
| 摘要 |
Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious from of a prion (PrP Sc ) is provided. |
| 申请公布号 |
ZA200408456(B) |
申请公布日期 |
2008.12.31 |
| 申请号 |
ZA20040008456 |
申请日期 |
2004.10.19 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BURTON, DENNIS R;MORONCINI, GIANLUCA;WIILLIAMSON, ANTHONY R |
| 分类号 |
G01N33/53;C07K14/47;C07K16/10;C07K16/18;C07K16/42;C07K16/46;C07K19/00;C12N;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/62;C12Q1/02;G01N33/68 |
主分类号 |
G01N33/53 |
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