发明名称 N-triiodobenzyl-carbamic acid derivatives
摘要 Water-soluble salts of pharmaceutically acceptable bases with N-(2,4,6-triiodo-3-acylamino-5-carboxy-benzyl)-carbamic acid esters of the formula COOH ¦ R2-CO-NHCH2-NH-CO-OR1 n ARE RELATIVELY NON-TOXIC, QUICKLY EXCRETED X-ray contrast agents suitable for intravenous administration. The carboxylic acids of the formula are monoesters of alcohols R1OH having up to four carbon atoms which are alkanols, mono- and dihydroxyalkanols, or alkoxyalkanols, when n is 1, and diesters of alcohols HO-R1-R1OH having up to 10 carbon atoms which are alkanediols or ethyleneglycol ethers when n is 2. R2 has up to three carbon atoms and is alkyl, hydroxyalkyl, or alkoxyalkyl.
申请公布号 US3910989(A) 申请公布日期 1975.10.07
申请号 US19740482665 申请日期 1974.06.24
申请人 BRACCO INDUSTRIA CHIMICA, SOCIETA PER AZIONI 发明人 FELDER, ERNST;PITRE, DAVIDE
分类号 A61K49/04;C07C67/00;C07C239/00;C07C269/00;C07C271/22;(IPC1-7):C07C125/06 主分类号 A61K49/04
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