| 摘要 |
1451181 2 - Nicotinamides - 1 - nicotinoyloxy- 0-glycopyranoses F HOFFMAN-LA ROCHE AG 24 Jan 1975 [25 Jan 1974] 3180/75 Heading C2C Novel compounds I in which R is C 1-6 alkanoyl, C 1-6 alkoxy C 1-6 alkanoyl or aryl are prepared by replacing X in a compound II where X is halogen or optionally protected hydroxy, by a nicotinoyloxy group in known manner. Compounds I (R=acetyl, propionyl, benzoyl) are prepared. Compound II (X=Cl, R=acetyl) is prepared by reacting N-nicotinoyl-D-glucosamine with acetyl chloride. Compound II (X=acetoxy, R=acetyl) is prepared by reacting 1,3,4,6- tetra - O - acetyl - D - glucosamine with nicotinic acid. Compounds I have plasma lipid-lowering activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or rectally. |
