发明名称 |
Modulation of stem cell differentiation by modulation of caspase-3 activity |
摘要 |
Methods of directing stem cell fate for therapeutic purposes through the deliberate manipulation of caspase-3 activity are provided. The use of modulators of caspase-3 activity to modulate stem cell differentiation is described including activators and/or effectors of caspase-3, which can be used to induce stem cell differentiation, and inhibitors of caspase-3, which can be used to inhibit differentiation and thereby promote or maintain proliferation of stem cells. Methods of screening for modulators of caspase-3 and the use of such compounds to modulate stem cell differentiation in vitro or in vivo are also provided as are therapeutic applications of the compounds.
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申请公布号 |
US2006100131(A1) |
申请公布日期 |
2006.05.11 |
申请号 |
US20050538767 |
申请日期 |
2005.06.10 |
申请人 |
MEGENEY LYNN;FERNANDO PASAN |
发明人 |
MEGENEY LYNN;FERNANDO PASAN |
分类号 |
A61K38/18;A61K31/70;C12N5/077;C12N5/0793;C12Q1/00;C12Q1/37;C12Q1/68;G01N33/573 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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