Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in -20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.
申请公布号
WO2004082458(A3)
申请公布日期
2006.05.11
申请号
WO2004US04452
申请日期
2004.02.18
申请人
THE JOHNS HOPKINS UNIVERSITY;BARDELLI, ALBERTO;PARSONS, WILL;VELCULESCU, VICTOR;KINZLER, KENNETH, W.;VOGELSTEIN, BERT