| 摘要 |
A compound represented by the formula (I): (I) [wherein Ar represents a divalent group formed by removing two hydrogen atoms from benzene, etc.; Xrepresents nitrogen, sulfur, or oxygen; Rrepresents 5- or 6-membered heteroaryl, etc.; ring A represents 5- or 6-membered heteroaryl ring, etc.; Rand Reach represents amino, alkylamino, etc.; and -Xrepresents, e.g., a group represented by the formula (II): (II) (wherein Rand Reach represents lower alkyl, etc.; and n is an integer of 2 to 4)] or a pharmaceutically acceptable salt of the compound. The compound or salt has antagonistic activity against a histamine H3 receptor or inverse agonistic activity against a histamine H3 receptor and is useful in the prevention or treatment of metabolic diseases, circulatory diseases, or neurotic diseases.(1),(II) |
