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发明名称
含有流行性感冒疫苗之冷冻乾燥制剂及其制造方法
摘要
本发明之目的在于提供一种流行性感冒疫苗之安定性业经改善的冷冻乾燥制剂。即,令满足下述(A)~(C)条件之水溶液冷冻乾燥,藉此制得流行性感冒疫苗安定性获显着改善之冷冻乾燥制剂:(A)含有(i)流行性感冒疫苗、(ii)疏水性胺基酸及(iii)精胺酸及其酸附加盐;(B)相对于所得冷冻乾燥制剂总量,前述(iii)成分系添加20~85重量%;以及(C)藉由控制构成前述(iii)成分之精胺酸及其酸附加盐之比例,而调整成pH8~10。
申请公布号
TW200848074
申请公布日期
2008.12.16
申请号
TW097108118
申请日期
2008.03.07
申请人
大塚制药股份有限公司
发明人
山下亲正
分类号
A61K39/145(2006.01);A61K9/19(2006.01)
主分类号
A61K39/145(2006.01)
代理机构
代理人
恽轶群;陈文郎
主权项
地址
日本
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