| 摘要 |
THE PRESENT INVENTION RELATES TO A COMPOUND OF FORMULA I:AND ANTITUMOR METHODS.WHERE:X IS O OR NH;R1 IS HYDROGEN, HALO, C1-C6 ALKYL, C1-C4 AIKOXY, C1-C4 ALKYLTHIO, CF3, OCF3, SCF3, (C1-C4 ALKOXY)CARBONYL, NITRO, AZIDO, O(SO2)CH3, N(CH3)2, HYDROXY, PHENYL, SUBSTITUTED PHENYL, PYRIDINYL, THIENYL, FURYL, QUINOLINYL, OR TRIAZOLYL;R2 IS HYDROGEN, HALO, CYANO, CF3, C1-C6 ALKYL, (C1-C4 AIKOXY)CARBONYL, C1-C4 ALKOXY, PHENYL, OR QUINOLINYL;R2A IS HYDROGEN OR C1-C4 ALKOXY;R2B IS HYDROGEN OR C1-C6 ALKYL PROVIDED THAT AT LEAST ONE OF R2A AND R2B IS HYDROGEN;R3 IS HYDROGEN, HALO, C1-C6 ALKYL, CF3, OR NITRO;R3A IS HYDROGEN, HALO, OR C1-C6 ALKYL PROVIDED THAT WHEN R3A IS C1-C6 ALKYL, R3 IS HYDROGEN AND R4 IS HALO; ANDR4 IS HALO, C1-C6 ALKYL, OR CF3 PROVIDED THAT ONLY ONE OF R3 AND R4 MAY BE C1-C6 ALKYL AND PROVIDED THAT WHEN R4 IS HALO OR C1-C6 ALKYL ONLY ONE OF R3 AND R3A IS HYDROGEN; OR A PHARMACEUTICALLY ACCEPTABLE BASE ADDITION SALT THEREOF, PROVIDED THAT:A) WHEN R3 AND R4 ARE BOTH CHLORO AND R2 IS HYDROGEN, R1 IS BROMO, IODO, C1-C4 ALKOXY, C1-C4 ALKYLTHIO, CF3, OCF3, NITRO, AZIDO, O(SO2)CH3, N(CH3)2, HYDROXY, PHENYL, SUBSTITUTED PHENYL, PYRIDINYL, THIENYL, FURYL, OR TRIAZOLYL;WHEN R3 AND R4 ARE BOTH CHLORO AND R1 IS HYDROGEN, R2 IS BROMO, FLUORO, CF3, C1-C6ALKYL, C1-C4 AIKOXY, PHENYL, OR QUINOLINYL.
|
