<p>Stable liquid pharmaceutical compositions comprising an antagonist anti- CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody -containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.</p>
申请公布号
WO2007124299(A8)
申请公布日期
2008.11.06
申请号
WO2007US66757
申请日期
2007.04.17
申请人
NOVARTIS AG;XOMA TECHNOLOGY LTD.;LU, XIAOFENG;CHEN, BAO-LU;ARAYA, KIDISTI;OKHAMAFE, AUGUSTUS
发明人
LU, XIAOFENG;CHEN, BAO-LU;ARAYA, KIDISTI;OKHAMAFE, AUGUSTUS