CYCLIC PEPTIDE ANTIFUNGAL AGENTS AND PROCESS FOR PREPARATION THEREOF

摘要

PROVIDED ARE COMPOUNDS OF THE FORMULA (1):FORMULA 1WHEREIN R'' IS HYDROGEN, METHYL OR NH2C(O) CH2-;R'''' IS METHYL OR HYDROGEN;R IS HYDROXY OR HYDROGEN;R1 IS HYDROXY, HYDROGEN, OR HYDROXYSULFONYLOXY;R7 IS HYDROXY, HYDROGEN, HYDROXYSULFONYLOXY OR PHOSPHONOOXY;R2 IS A NOVEL ACYL SIDE CHAIN. ALSO PROVIDED ARE NOVEL FORMULATIONS, METHODS OF INHIBITING FUNGAL AND PARASITIC ACTIVITY, AND A PROCESS FOR PREPARING DIDEOXY (R=H) FORMS OF THE COMPOUNDS.