METHODS FOR PREDICTING PSYCHOTROPIC DRUGS WHICH ELICIT WEIGHT GAIN
摘要
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine Hl receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake.
申请公布号
WO2008036175(A3)
申请公布日期
2008.10.30
申请号
WO2007US19617
申请日期
2007.09.10
申请人
THE JOHNS HOPKINS UNIVERSITY;SNYDER, SOLOMON, H.;HUANG, ALEX;TEUSCHER, CORY;KIM, SANGWON