发明名称 |
CONTROLLED RELEASE MULTIPLE LAYER COATINGS |
摘要 |
<p>A process for making controlled release pharmaceutical formulations is provided, which comprises supplying a plurality of solutions with syringe pumps for fluid bed coating, coating a substrate with a pH dependent soluble polymer solution, coating the polymer coated substrate with at least one layer of a solution of a therapeutically active substance and at least one layer of a second polymer solution, and alternating the layers so that the number, order, and volume of the layers controls the release of the therapeutically active substance. In alternate embodiments, the consecutively applied layers may contain coating materials, active ingredients or a mixture of coating materials and active ingredients; the layers can be applied in varying order. Also provided is a system for applying the coatings, wherein the syringe pumps are controlled by a computer in accordance with predetermined instructions.</p> |
申请公布号 |
WO2008129507(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
WO2008IB51529 |
申请日期 |
2008.04.21 |
申请人 |
XAVIER UNIVERSITY OF LOUISIANA;MANDAL, TARUN KUMAR;CHINTA, DAKSHINAMURTHY DEVANGA;GRAVES, RICHARD A. |
发明人 |
MANDAL, TARUN KUMAR;CHINTA, DAKSHINAMURTHY DEVANGA;GRAVES, RICHARD A. |
分类号 |
A61K9/16;A61K9/50;A61K31/138 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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